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Tammy Dugas

Professor, Department of Comparative Biomedical Sciences, LSU School of Veterinary Medicine

LSU Superfund Research Program Oxidative Stress Core leader.  




Phone: (225) 578-7581

Fax: (225) 578-9895




Research interests, expertise:

  • Mechanisms of cardiovascular injury induced by environmental toxicants and by pharmaceuticals
  • Mechanisms for cardioprotection by red wine polyphenols


Recent publications:


Lee, G., Saravia, J., You, D., Shrestha, B., Jaligama, S., Hebert, V., Dugas. T., Cormier, S. 2014. Exposure to Combustion Generated Environmentally Persistent Free Radicals Enhances Severity of Influenza virus Infection. Part Fibre Toxicol. 11(1):57. Doi:10.1186/s12989-014-0057-1. [Epub ahead of print]


Lomnicki, S., Gullett, B, Stöger,T., Kennedy, I., Diaz, J., Dugas, T.R., Varner, K., Carlin, D., Dellinger, B., and Cormier, S.A. 2013. Combustion By-Products and their Health Effects - Combustion Engineering and Global Health in the 21st Century: Issues and Challenges. International Journal of Toxicology. 33(1):3-13. Doi: 10.1177/1091581813519686. PMCID: PMC3944372 



Kelley, M.A., Hebert, V.Y., Thibeaux, T.M., Orchard, M.A., Hasan, F., Cormier, S.A., Thevenot, P.T., Lomnicki, S.M., Varner,K.J., Dellinger, B, Latimer, B.M., Dugas, T.R. 2013. Model Combustion-Generated Particulate Matter Containing Persistent Free Radicals Redox Cycle to Produce Reactive Oxygen Species. Chem. Res. Toxicol. 26(12):1862-71. Doi: 10.1021/tx400227s.


Thevenot, P., Saravia, J., Giammo, J., Happel, K.I., Dugas, T.R. and Cormier, S.A. 2013. Chronic Alcohol Induces M2 Polarization Enhancing Pulmonary Disease Caused by Exposure to Particulate Air Pollution. Alcoholism: Clinical and Experimental Research. 37(11): 1910-1919.Doi: 10.1111/acer.12184. PMCID: PMC3775861


Thevenot P.T., Saravia J., Jin N, Giaimo J.D., Chustz R.E., Mahne S., Kelley M.A., Hebert V.Y., Dellinger B., Dugas T.R., Demayo F.J., Cormier S.A. 2013. Radical-containing ultrafine particulate matter initiates epithelial-to-mesenchymal transitions in airway epithelial cells. American Journal of Respiratory Cell and Molecular Biology. 48:188-197. Doi: 10.1165/rcmb.2012-0052OC. PMCID: PMC3604062


Xue, S.Y., Hebert, V.Y., Hayes, D.M., Robinson, C.N., Glover, M., and Dugas, T.R. 2013. Nucleoside reverse transcriptase inhibitors induce a mitophagy-associated endothelial cytotoxicity that is reversed by coenzyme Q10 cotreatment. Toxicol Sci. 134(2):323-34.



Khandelwal, A.R., Hebert, V.Y., Kleinedler, J.J., Rogers, L.K., Ullevig, S.L., Asmis, R., Shi, R., Dugas, T.R. 2012. Resveratrol and quercetin interact to inhibit neointimal hyperplasia in mice with a carotid injury. J Nutr. 142(2):1487-94.


Kleinedler, J.J., Pjescic, I., Bullock, K.K., Khaliq, A., Foley, J.D., Dugas, T.R. 2012. Arterial pharmacokinectics of red wine polyphenols: implications for novel endovascular therapies targeting restenosis. J Pharm Sci. 101(5):1917-31.


Kleinedler, J.J., Foley, J.D., Orchard, E.A., Dugas, T.R. 2012. Novel nanocomposite stent coating releasing resveratrol and quercetin reduces neointimal hyperplasia and promotes re-endothelialization. J Control Release. 159(1):27-33.



Kelley, M.A., Thibeaux, T., Hebert, V., Cormier, S.A., Lomnicki, S., Dillinger, B., Dugas, T. 2011. Model Particulate Matter Containing Persistent Free Radicals Exhibit Reactive Oxygen Species Production. Free Radical Biology and Medicine. 51(1):S134. 


Lord, K., Moll, D., Lindsey, J.K., Mahne, S., Raman, G., Dugas, T., Cormier, S., Troxlair, D., Lomnicki, S., Dellinger, B., & Varner, K. 2011. Environmentally persistent free radicals decrease cardiac function before and after ischemia/reperfusion injury in vivo. J Recept Signal Transduct Res. 31(2):157-67. Doi: 10.3109/10799893.2011.555767. PMCID:PMC3152960



Khandelwal, A.R., Hebert,V.Y., Kleiner, H.E., and Dugas, T.R. 2010. Essential role of an ER-α dependent production of nitric oxide in modulating the anti-restenotic effects of resveratrol. Am. J. Physiol. Heart & Circ. Physiol. 299:H1451-1458.


Jiang, B., Khandelwal, A.R., Rogers, L.K., Zavecz, J.H., Shi, W., Orr, A.W., and Dugas, T.R. 2010. Antiretrovirals induce endothelial dysfunction via an oxidant-dependent pathway and promote neointimal hyperplasia in C57BL/6 mice. Toxicol. Sci. 117:524-36.